The first of three games to be played in London this season marks Jacksonville’s fourth trip to Wembley Stadium in as many years. This time, it “hosts” Indianapolis in a must-win AFC South matchup.

WEEK 4 PICKS: Straight up | Against the spread

The Colts, on the other hand, have never played across the pond. But they also are in need of a division win, having started the season 1-2 and chasing the 2-1 Texans. Andrew Luck has been victorious in each of his last five starts against the Jaguars, who enter Week 4 winless.

Sporting News NFL writers David Steele and Vinnie Iyer think both streaks will continue. Here are their predictions for Sunday’s game.

Colts-Jaguars picks

STEELE: Colts, 24-13 — A double-bad omen for the Jaguars is looming. In each of the last two seasons, a team has followed a loss in London by firing its coach (the Raiders, then the Dolphins). Also last year, the Lions nuked their president and general manager after a London rout. Gus Bradley is 12-39 in Season 4. Meanwhile, only one team has ever made the playoffs after starting 0-4, the 1992 Chargers. This seems like a must-win.

IYER: Colts, 24-23 — This is a pretty good game to ship over to London, given Indianapolis is a whimpering 1-2 and Jacksonville is a sputtering 0-3. The offensive lines aren’t very good, and neither team has enough healthy defensive pieces. On paper, it looks like a shootout, but strange things happen across the pond on bad Wembley turf. Luck can fight through what’s ailing the rest of his team a little better than Blake Bortles, and that makes the slightest difference.

FANTASY: Week 4 QB rankings | RB | WR | TE | D/ST

Colts-Jaguars game info

Kickoff time: 9:30 a.m. ET

Live stream: Nope — not this time

TV coverage: CBS (national)