Symptoms The symptoms of Coffin-Lowry syndrome, which tend to be more severe in men, become more prominent with age. These include: Intellectual Disability: The scope of this symptom ranges from mild to profound intellectual disability, with some people with this condition never developing speech abilities. Broad Facial Features: Especially prominent in males and most visible in late childhood, those with Coffin-Lowry syndrome have a prominent forehead, widely-spaced and downwardly slanted eyes, a shorter, wide nose, as well as a wider mouth with thicker lips....

A post on Coinbase’s blog says the SEC has issued the company with a Wells notice—a message of intent to sue in court. The blog post, written by Coinbase’s chief legal officer Paul Grewal, states that the warning was issued over the platform’s proposed Lend program, which would allow cryptocurrency owners to lend them in return for interest. According to Reuters, some U.S. states have raised concerns about such programs, arguing that they should comply with existing securities laws....

Hamels, 31, doesn’t believe the club can win, and he’d prefer to be pitching for a team that has a chance to make the playoffs. MORE: NL offseason grades | Amaro says four ‘real’ offers for Hamels | Penciled in to start Phils’ opener “I just want to win,” Hamels told USA Today Sports in his first interview since the end of the 2014 season. “That’s all. That’s all any competitor wants....

With Kaepernick’s future in San Francisco a bit murky, Harbaugh said if anyone inquired about his former quarterback, he would give a glowing report. MORE: Best, worst of five years of free agency | Seven NFL rule changes for 2016 “Anybody that talks to me is going to get a great recommendation that’s going to knock their socks off,” Harbaugh told The Sacramento Bee . Discord between Kaepernick and the 49ers appeared after Harbaugh left to coach Michigan at the end of the 2014 season....

Kaepernick, through a little more than a quarter in Buffalo, gave San Francisco’s offense the passing spark it needed. His early passer rating was a near-perfect 153.3, going 5-for-7 for 103 yards, including a 53-yard touchdown to speedy wide receiver Torrey Smith in the second quarter. MORE: 49ers-Bills updates | NFL scoreboard Kaepernick overshot Smith on a potential scoring deep ball in the first quarter. He had not done much running early in the game, with 3 attempts for only 9 yards, but everyone knows he can be much more dynamic than the athletic Gabbert....

The 49ers quarterback was joined by teammate Eric Reid, and the two of them knelt on the sideline as “The Star-Spangled Banner” was performed by a Navy petty officer at San Diego’s Qualcomm Stadium before the 49ers played the Chargers on Thursday night. MORE: Worst of the Kaepernick takes Reid is from Baton Rouge, La., where an African-American man, Alton Sterling, was fatally shot by police officers in July....

Enjoy, dear readers. ACC MEDIA POLL 1. Duke 2. Syracuse 3. North Carolina 4. Virginia 5. Notre Dame 6. Pitt 7. Maryland 8. Boston College 9. Florida State 10. NC State 11. Georgia Tech 12. Miami 13. Wake Forest 14. Clemson 15. Virginia Tech AMERICAN COACHES POLL 1. Louisville 2. Connecticut 3. Memphis 4. Cincinnati 5. Temple 6. SMU 7. Houston 8. USF 9. UCF 10. Rutgers ATLANTIC 10 COACHES/MEDIA POLL 1....

The NCAA has clearly defined periods throughout the summer when college coaches can and cannot contact, visit or observe high school players. These are called “live,” “quiet” and dead periods, and each period permits college coaches and recruiters to do different things. MORE: Best states for college hoops | Top 25 players in the Class of 2015 | Way too early 2016 predictions During any live period, college coaches may take part in any of the following: Unofficial visits, official visits, off-campus/home visits, letters, emails, calls/texts and evaluating the player during his high school/prep/AAU competitions....

Fantasy Alarm’s Playbook PRO includes full analysis for every pick, optimal lineups for FanDuel and DraftKings, a live DFS scoreboard to track your players and much more. Not only do you get the College Fantasy Football Playbook with your Playbook PRO subscription, you also get access to even more great content in the NFL, NBA and MLB Playbooks, along with all of Fantasy Alarm’s DFS tools and strategies! Check out this week’s free college fantasy football picks below, and check out FantasyAlarm....

After serving as offensive coordinator and quarterback coach since 2017, Ryan Day was named as the Buckeyes new head coach in December last year when Urban Meyer stepped down. To suggest the 40-year-old has big shoes to fill would be an understatement. In seven seasons with the Buckeyes, Meyer went 83-9 with a cumulative 54-4 record in Big Ten games. Meyer won the national championship in 2014 and took Ohio State to the Big Ten Championship Game on other four occasions....

Clemson reached the final by rolling past No. 3 Notre Dame (12-1) in the Cotton Bowl. Alabama (14-1) advanced to the championship round — and set up a third CFP title game with Clemson in four seasons — by outpacing No. 4 Oklahoma (12-2) in the Orange Bowl. MORE: Four-team Playoff is imperfect, but will be missed Here are all 40 college football bowl game matchups for 2018-19: 2018-19 College Football Playoff schedule 2018-19 New Year’s Day Six schedule 2018-19 College Football Bowl schedule

“The first thing that came to mind when I see this game moving is, is Dak Prescott not playing?” Avello said of the Mississippi State quarterback and Heisman Trophy contender. “The game to me, it’s a touchdown game. I do realize that Alabama’s beaten this team a bunch of times in a row, and none of the games have been close. But I think this is a different Mississippi State team that they’re playing here....

There are five matchups between AP Poll top-25 teams this week, including No. 4 Ohio State at No. 9 Penn State, No. 7 Stanford at No. 8 Notre Dame, No. 12 West Virginia at No. 25 Texas Tech, No. 19 Oregon at No. 24 Cal and No. 20 BYU at No. 11 Washington. MORE: Week 5 bowl projections Sporting News is here to offer its straight up picks for those games and more....

Several Vegas sports books on Sunday opened Alabama -9.5 vs. the Spartans in the Goodyear Cotton Bowl, with the line getting bet up to -10 at MGM Resorts. The Wynn opened the game -8.5 and moved to -9. On Monday morning, most shops are dealing -9.5, with -9s available for bettors looking to lay the points early. “I give ‘em a puncher’s chance here against Alabama,” John Avello, head oddsmaker at The Wynn, told The Linemakers of Michigan State....

No. 1 Alabama retained its stranglehold in the Interactive College Football Poll. Florida State remained No. 2. Both schools held their ground in the USA Today coaches poll as well as the AP Top 25. Baylor moved into third in the AP rankings, but the Harris Poll agreed with coaches in placing the Buckeyes in that slot. Contributing: Associated Press

There also will be College Football Playoff implications — after all, no weekend generates more over-the-top reactions than the first. MORE: SN’s preseason top 25 Sporting News breaks down the best games of college football’s opening weekend, from the Thursday before through Labor Day. (All times Eastern) 12. Texas at Maryland Noon, Saturday, Fox Sports 1 Maryland hung 51 on Texas in Austin last season, and the Terps are healthy again heading into D....

We’re still 13 weeks away from the release of the College Football Playoff pairings, but that won’t stop us from sorting out what’s fact and fiction from the top trends from the opening weekend. Here’s what’s being talked about most now, and whether we’re buying or selling. MORE: Week 1 highlights Tua vs. Trevor for the title! Buy. Tua Tagovailoa took control of the Alabama quarterback battle with an efficient performance in a 51-14 victory against Louisville....

In 2014, Mississippi State was sporting a spiffy 9-0 record and was deemed No. 1 by the inaugural CFP committee. Game 10 was at Alabama, and the Bulldogs were a 9.5-point underdogs. Alabama won 25-20, kicking off a close to the season where Mississippi State lost three of its final four, including a 49-34 defeat to Georgia Tech in the Orange Bowl. So can the top-ranked Vols “upset” No. 3 Georgia as 8-point underdogs?...

MORE: Mets minor-league affiliate to wear glow-in-the-dark uniforms Fans can vote online for their top five emoji choices out of 100 options listed on the website (but don’t be 💔 if you don’t see your favorite — there is a write-in option). The votes will be tallied and the top 25 emojis will be featured on the uniforms during the team’s game Aug. 13 against the Rockford Rivets. Voting is open until March 1....